Disclosure: This review contains affiliate links. I may earn a commission if you buy through them, at no extra cost to you. Written by Michael Montoya. Last updated: November 8, 2026.
Around the mid-forties, a lot of women notice their body acting differently: more cravings, energy that dips in the afternoon, weight that settles around the middle, and sleep that isn’t what it was. Perimenopause and menopause change hormones, and many supplements now promise to help with that.
Arrae MB-1 45+ is one of them. Arrae markets it as “Formulated for perimenopause, menopause & beyond to support metabolic and hormonal shifts with clinically studied ingredients.”
I wanted to know what’s actually in it, what the “clinically studied” claims are based on, who should be careful with it, and what buyers say. I went through Arrae’s product page and refund policy, the government health pages on its main ingredients, Trustpilot, and the BBB.
A two-capsule daily supplement for women 45+ with branded extracts for appetite, metabolism, stress, sleep, and menopause comfort. Promising ingredients, but no study of the finished formula; check with a doctor if you take medicine.
- Made for perimenopause and menopause
- Branded, studied ingredients
- Brand says third-party tested, COA linked
- 4.51 out of 5 from 1,346 reviews on Arrae's page
- Claims rest on ingredient studies, not the product
- Proprietary blend hides amounts
- Contains caffeine and ashwagandha
- Refunds cover one jar only
Quick Verdict
MB-1 45+ is a reasonable non-prescription option for women in perimenopause or menopause who want help with cravings, energy, stress, and sleep, and who’ll give it three months. Most of its key ingredients are branded extracts with their own studies, and Arrae says it’s third-party tested. The catch: every percentage on the page comes from ingredient research, not a study of this product; it contains caffeine and ashwagandha, which some people should avoid; and refunds cover only one jar. On Arrae’s page it rates 4.51 out of 5, while Arrae’s unclaimed Trustpilot profile sits at 1.5; the recent reviews I read there were about service and other Arrae products.
About Arrae MB-1 45+
MB-1 45+ is a daily capsule supplement from Arrae, sold as “Metabolism support for women 45+.” It’s a version of Arrae’s MB-1 line, which also includes the original MB-1 and an extra-strength MB-1 Max. The 45+ version adds ingredients aimed at menopause: an ashwagandha extract for stress and sleep, and a probiotic blend that Arrae says supports “Estrogen preservation for menopause comfort.”
The brand says it supports four things: GLP-1 function for appetite, estrogen through the gut, lower cortisol, and metabolism. Every one of those claims carries an asterisk, and the page’s footer explains why: “These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.”
That’s standard for supplements, and it’s worth keeping in mind through the rest of this review. The FDA says, “Under DSHEA, FDA does not have the authority to approve dietary supplements before they are marketed.”
What’s Inside Arrae MB-1 45+?
Arrae’s current product page lists eight active ingredients. Most are branded extracts, which means a supplier has done its own studies on that specific extract.
Key Ingredients Inside Arrae MB-1 45+:
- DygloFit® (African pepper fruit extract): Arrae says it “supports natural GLP-1 function to support balanced appetite, improved satiety, and healthy weight management.”
- IGOB131® (African mango seed): sold for weight management and “balanced hunger hormones,” per Arrae.
- KSM-66® (ashwagandha root extract): Arrae says it’s “been shown to lower cortisol levels to support healthy stress response, emotional balance, and improved sleep quality.”
- CaloriBurn GP® (grains of paradise): a spice extract Arrae says was studied “to increase resting metabolic rate, daily calorie burn & energy expenditure.”
- Gyntima® (probiotic blend): three probiotic strains Arrae links to estrogen and menopause comfort.
- Green tea extract: for “clean energy,” and the source of the formula’s caffeine.
- Vitamin B6 (as P5P): 10mg per serving.
- Chromium picolinate: 500mcg per serving, for “healthy blood sugar maintenance,” per Arrae.
Two details matter here. First, the main extracts sit in a “Proprietary Blend – 1.35g,” so the label doesn’t show how much of each one you get. Second, the product page has two ingredient lists, and only one of them includes KSM-66 ashwagandha; the “Supplement Facts” version I saw leaves it out. I’d check the label on the jar you receive.
I’ve dropped Cissus (CQR-300) and the probiotic B420, which this review listed before; neither appears on Arrae’s current page.
Format, Label, And Directions
The product page and the label in its photos answer a few basics.
The Jar And Capsule Count
The jars in the photos on this page show different capsule counts, 40 on one and 60 on others, so check the count on your order. Arrae lists a single purchase as a “1 month supply.”
What The Label Says It Is
The jar is labeled “DIETARY SUPPLEMENT,” and the product page says it’s “Third-party tested,” with a link to view a certificate of analysis. I’d count that as a plus, since many supplement brands don’t share test results at all.
How Many Capsules A Day
The directions are simple: “Take 2 MB-1 45+ capsules daily, ideally in the morning or before your workout.”
Caffeine And Timing
Arrae notes that “MB-1 45+ contains naturally-sourced Green Tea caffeine” and recommends taking it earlier in the day. I didn’t see a caffeine amount on the page, which matters if you drink coffee or are sensitive to caffeine.
The FDA Note
As noted above, the claims carry the FDA disclaimer. That isn’t a red flag by itself, but it means the FDA hasn’t evaluated these claims.
What Arrae Says To Expect, And The Evidence Behind It
Arrae’s page has a month-by-month timeline and several percentages. Each one comes with the same small note: “Based on individual ingredient research.” In other words, the numbers come from studies on single ingredients, not from a study of MB-1 45+ itself. Below is each promised benefit and what it rests on.
Setting Expectations
The brand recommends “daily use for 3 months alongside a balanced diet and active lifestyle.” So this isn’t a quick fix, and the brand doesn’t say it is. Any change will also be hard to separate from the diet and exercise that come with it.
Cravings
In month one, the timeline says “Cravings start to calm.” That claim leans on DygloFit, IGOB131, and chromium, which Arrae says “can help with cravings.” It’s a reasonable target for these ingredients, but I didn’t find a study on the finished product.
Energy
The timeline promises “Improvements in daily energy” in month one. The most direct source of energy here is the caffeine in green tea extract. If you already drink coffee, that effect may be small.
Digestion
The probiotic blend is there for estrogen, according to Arrae, not digestion. Arrae’s auto-generated review summary does say reviewers praise it for “reducing bloating,” but I’d treat that as buyer feedback, not a tested effect.
Appetite And GLP-1
The headline claim is “Healthy GLP-1 function for appetite regulation.” To be clear, MB-1 45+ isn’t a GLP-1 drug, and Arrae says it’s “not intended to replace HRT or any other prescribed treatment, nor is it a treatment for medical conditions such as diabetes or obesity.” The GLP-1 wording refers to ingredient research on DygloFit.
Mood And Stress
Arrae says KSM-66 gives “Up to 16.4% cortisol reduction for stress & mood support.” That’s from ashwagandha research. The government’s NCCIH page says ashwagandha “may be safe when taken in the short term (up to 3 months),” but there isn’t enough information on long-term safety.
Sleep
The page claims “Up to 35.2% improvement in sleep quality with KSM-66®.” That’s an ingredient figure too. Since the formula also contains caffeine, taking it early in the day, as Arrae advises, makes sense.
Bloating
I didn’t find a bloating claim in Arrae’s list of benefits for MB-1 45+, only in its review summary. Since bloating isn’t one of Arrae’s listed benefits, I wouldn’t buy this for that alone.
The Brand’s Timeline
The timeline covers three months: month one, “Cravings start to calm”; month two, “Hunger hormones are more balanced” with better mood and sleep; month three, “Up to 18% reduction in body fat” and “Supported estrogen for menopause comfort.” Those are goals based on ingredient studies, not a promise for any one person.
What This Means Day To Day
In practice, MB-1 45+ is two capsules each morning for the three months Arrae recommends, alongside the diet and activity Arrae recommends. It’s fair to judge it on whether cravings, energy, and sleep improve by then. Step 6 below has a simple way to track that.
Pros and Cons of Using Arrae MB-1 45+
My take, based on Arrae’s page, government health sources, and reviews:
How Arrae MB-1 45+ Is Meant To Work
Arrae describes several ways the formula is meant to work. For each, I note what I could and couldn’t confirm.
Natural Support for GLP-1
GLP-1 is a gut hormone involved in fullness. Arrae says DygloFit “supports natural GLP-1 function.” That’s a claim about the ingredient. It doesn’t make MB-1 45+ comparable to prescription GLP-1 medicines, and Arrae itself says it isn’t a treatment for obesity.
Activation of the AMPK Switch
This review used to say MB-1 45+ helps activate AMPK. I didn’t find that claim on Arrae’s current product page, so I can’t stand behind it, and I’ve left it out.
Support for Blood Sugar and Cholesterol
Arrae says chromium picolinate “supports healthy blood sugar maintenance,” marked with a separate symbol. The earlier version of this page quoted a 31 percent drop in blood sugar and a 44 percent drop in cholesterol. Those numbers aren’t on Arrae’s current page, and I couldn’t trace them, so I’ve removed them. If you have diabetes or take blood sugar medicine, talk to your doctor first; NCCIH says ashwagandha may interact with diabetes medicines.
Body Fat Claims
The page says “Up to 18% reduction in body fat with DygloFit®.” That’s the best case from one ingredient’s research, labeled “up to,” and Arrae pairs it with diet and exercise. I’d treat it as the top of the range, not the expected result.
Calorie Burn Claim
CaloriBurn GP is said to support thermogenesis, with “UP TO 97” more calories burned per day. Even at the top of that range, it’s a small number compared with a typical day’s food, so it won’t do much without changes to diet and activity.
Estrogen And The Gut
This is the most detailed claim. The page cites “a 3-month randomized, double-blind, placebo-controlled study involving 210 peri- and postmenopausal women,” in which the Gyntima probiotic “significantly improved overall menopause symptom scores compared with placebo.” The chart on the page shows both groups improving, with the probiotic group improving somewhat more. It’s a real study design, but on the ingredient, not on MB-1 45+.
Based On Ingredient Research, Not The Product
Put together, the formula combines ingredients that each have some research behind them. What’s missing is a study of the full MB-1 45+ formula. That doesn’t mean it won’t help, but it does mean the percentages aren’t a prediction for you.
Who Arrae MB-1 45+ Is Best For (and Who Should Skip It)
MB-1 45+ is built for a specific group, and some people should check with a doctor first or skip it.
Best For
- Women in perimenopause, menopause, or postmenopause, which Arrae says can start anywhere from the mid to late 30s to the mid-50s.
- People who want a non-prescription option and accept slower, smaller effects.
- Those willing to take it daily for three months alongside diet and activity changes.
- People who are fine with some caffeine in the morning.
Who Should Skip It
- Anyone pregnant or breastfeeding: NCCIH says ashwagandha “should be avoided during pregnancy and should not be used while breastfeeding.”
- People with thyroid or autoimmune disorders, or who are about to have surgery, per NCCIH’s ashwagandha guidance.
- Anyone taking medicine for diabetes, blood pressure, thyroid, seizures, or the immune system, or taking sedatives, since NCCIH lists possible ashwagandha interactions.
- People on HRT, GLP-1 drugs, or weight loss medicines, who Arrae says should consult their healthcare provider first.
- Anyone with liver problems: NCCIH calls liver injury rare with ashwagandha and uncommon with green tea extracts, but reported for both.
- People who want fast results; Arrae itself recommends three months.
How to Use Arrae MB-1 45+ for Best Results?
This photo came with the earlier version of this page. I couldn’t confirm who took it, and it doesn’t show the writer.
These steps follow Arrae’s own directions, plus a few common-sense habits I’d add.
Step 1: Begin With One Capsule if You Are New
Arrae says that if you’re new to metabolic products and sensitive to caffeine, “take one capsule around breakfast and one capsule around lunch to help your body adjust.” That splits the caffeine across the morning.
Step 2: Move to Two Capsules Daily
The standard dose is two capsules a day, “ideally in the morning or before your workout.” Don’t take more than the label says.
Step 3: Avoid Taking It Close to Bedtime
Because it contains green tea caffeine, Arrae recommends taking it earlier in the day. An evening dose could affect sleep, which is one of the things the formula is meant to help.
Step 4: Check With Your Doctor If You Take Medicine
If you take any medicine, this step matters most. Arrae recommends consulting your healthcare provider if you take prescribed medication, “including hormone replacement therapy (HRT), thyroid medication, weight loss medications, or GLP-1 drugs.”
Step 5: Pair It With A Balanced Diet
Arrae’s results claim assumes “a balanced diet and active lifestyle.” A supplement can’t make up for a poor diet.
Step 6: Stay Consistent for the Best Experience
Arrae recommends three months of daily use. I’d decide before you start how you’ll judge it, such as cravings, afternoon energy, or sleep, and note them weekly.
Step 7: Watch For Side Effects
NCCIH lists possible side effects of ashwagandha, including “drowsiness, stomach upset, diarrhea, and vomiting,” and of green tea extract, including nausea and abdominal discomfort. Stop and talk to a doctor if you notice anything unusual. NCCIH reports liver injury as rare with ashwagandha and uncommon with green tea extracts, so I wouldn’t ignore new symptoms.
Comparison With Similar Products
MB-1 45+ sits between general metabolism supplements and prescription GLP-1 medicines. Here’s how they differ in the basics.
| Feature | Arrae MB-1 45+ | General Metabolism Supplements | Prescription GLP-1 Medicines |
| Made for women 45+ | Yes | Usually not | No |
| Prescription needed | No | No | Yes |
| FDA approval before sale | No (dietary supplement) | No (dietary supplement) | Yes (drug) |
| Studied as a finished product | Not that I found; claims rely on ingredient research | Varies by product | Yes, in clinical trials |
| Menopause-focused ingredients | Yes (probiotic blend, ashwagandha) | Rarely | No |
| Contains caffeine | Yes (green tea) | Often | No |
| Doctor involved | Recommended if you take medicine | Recommended if you take medicine | Required |
The Main Difference
What sets MB-1 45+ apart from general metabolism supplements is the menopause focus: the probiotic blend and ashwagandha. What sets it apart from GLP-1 medicines is everything else: it’s not a drug, it hasn’t been tested as one, and it shouldn’t be expected to work like one. Arrae says as much on its own page.
If you’re considering a GLP-1 medicine, that’s a conversation for your doctor. If you want a gentler, non-prescription option and accept that the evidence is on the ingredients, MB-1 45+ is worth considering.
What Others Are Saying
The earlier version of this review quoted five named customers I couldn’t trace, so I’ve replaced them with reviews I could check.
On Arrae’s product page, MB-1 45+ is “Rated 4.51 out of 5, 1346 reviews.” The page’s auto-generated summary says “Reviewers highly praise MB-1 45+ from Arrae for reducing bloating, curbing cravings, boosting daily energy, and effectively easing perimenopause symptoms.” The featured quotes are picked by Arrae, such as Jen Ayres: “I recommend it to anyone that wants to feel good thats in perimenopause.” Seller-hosted reviews lean positive, so I read them as a best case.
Trustpilot tells a different story about the company. Arrae’s profile there is unclaimed and rated 1.5 out of 5 from 179 reviews, with 56% one-star. The recent reviews I read were about other Arrae products and about service, not MB-1 45+. A reviewer listed as CF wrote in October 2026, “Horrible customer service. 17 days after my order shipped and 10 days since the tracking stopped updating.” SK wrote, “Absolutely absurd customer service. My tribiotic subscription was delayed by 2+ weeks.” Stefani wrote, “It made me extremely nauseous the next day,” without naming the product.
The BBB lists Arrae in Richardson, Texas, with a B+ rating, one complaint in the last three years, and no BBB accreditation.
Arrae MB-1 45+ Claims Vs What I Found
I checked Arrae’s main claims against its own page and government health sources on November 8, 2026.
| Claim | What I found |
| “Up to 18% reduction in body fat with DygloFit®” | Marked “Based on individual ingredient research.” Not a study of MB-1 45+. |
| “Healthy GLP-1 function for appetite regulation” | An ingredient claim. Arrae says it’s not a treatment for obesity or a replacement for prescribed drugs. |
| “Up to 16.4% cortisol reduction” with KSM-66 | Ashwagandha research. KSM-66 is missing from one of the page’s two ingredient lists. |
| Gyntima study of 210 women | A randomized, placebo-controlled design per Arrae; both groups improved, the probiotic group more. |
| “Third-party tested” | A certificate of analysis is linked on the page. I didn’t verify the lab. |
| “over 1M+ women” use MB-1 formulas | Covers all MB-1 formulas; I couldn’t check it. |
Pricing of Arrae MB-1 45+
Arrae’s page offers four ways to buy MB-1 45+:
- 1 Time Purchase: a one-month supply, delivered once.
- 1 Month Delivery: a subscription marked “SAVE 20%.”
- 3 Month Delivery: a three-month supply every three months, marked “BEST VALUE SAVE 30%.”
- 6 Month Delivery: also listed as an option.
Subscriptions come with “Free shipping on every order” and “Skip, pause or cancel anytime,” according to the page. One-time orders get free shipping on orders of $100 or more. The page showed prices in my local currency, so check the current US price on Arrae’s page before ordering. The dollar prices in the earlier version of this review were out of date, so I’ve removed them.
Before choosing a subscription, read the refund terms below. Refunds cover one jar only, so a three-month delivery isn’t fully refundable if you change your mind.
Where to Buy?
MB-1 45+ is sold through Arrae’s own website, arrae.com, which is where the buttons on this page lead. Buying there gets you the current formula and the subscription options.
Arrae’s refund policy says you may request a refund “within 30 days from the date of delivery (minus shipping/ handling, VAT, or duties).” It adds that “Refunds apply to one jar of product only” and that refunds don’t cover “any subsequent shipments, even if they are billed, paid, or shipped during this 30-day period.” The item must be in its original packaging, and you start a return by emailing hello@arrae.com.
That one-jar limit matters most. If you’re unsure, I’d start with a one-time purchase rather than a multi-month subscription.
Frequently Asked Questions
These are the practical questions I’d want answered before ordering.
Can You Take Arrae MB-1 45+ With Morning Coffee?
Possibly, but be careful. MB-1 45+ contains green tea caffeine, and the page doesn’t say how much, so coffee adds to it. If you’re sensitive to caffeine, Arrae suggests splitting the two capsules between breakfast and lunch.
Is It Safe For Daily Use?
There’s no simple yes, and supplements aren’t approved by the FDA before sale. NCCIH says ashwagandha “may be safe when taken in the short term (up to 3 months),” with not enough data on longer use. Check with a doctor if you take any medicine.
Will It Affect Your Usual Workouts?
Arrae suggests taking it “in the morning or before your workout,” likely because of the caffeine. It won’t replace the effect of exercise itself, and Arrae’s results assume an active lifestyle.
Does It Have a Strong Taste or Smell?
I couldn’t find information on taste or smell on Arrae’s page. It comes as a capsule, so taste is unlikely to matter.
Is Arrae MB-1 45+ Easy To Travel With?
Yes, it’s a jar of capsules. Arrae also sells a separate “Travel ready case for your capsules.”
Has The FDA Reviewed Arrae MB-1 45+?
No. It’s a dietary supplement, and the FDA doesn’t approve supplements before they’re sold, as I noted near the top. Arrae’s page carries the standard FDA disclaimer.
Is It Safe During Pregnancy?
No, it isn’t a pregnancy product. NCCIH says ashwagandha “should be avoided during pregnancy and should not be used while breastfeeding,” and MB-1 45+ contains it. The formula is also made for women in perimenopause and later.
Can Men Take Arrae MB-1 45+?
It’s formulated for women in perimenopause and menopause, so its probiotic and menopause claims don’t apply to men. NCCIH also notes that ashwagandha may increase testosterone, so people with hormone-sensitive prostate cancer should avoid it. A man interested in the MB-1 line would be better off asking a doctor.
Is MB-1 45+ A GLP-1 Medication?
No. It’s a dietary supplement with ingredients that Arrae says support natural GLP-1 function. Arrae says it’s “not intended to replace HRT or any other prescribed treatment.”
Can You Take It With HRT Or GLP-1 Drugs?
Ask your doctor first. Arrae says, “Though we are not aware of any interactions,” you should consult your healthcare provider if you take HRT, thyroid medication, weight loss medications, or GLP-1 drugs.
Is There A Refund If It Doesn’t Work?
Yes, within 30 days of delivery, for one jar only, minus shipping and duties. Later subscription shipments aren’t refundable.
Final Verdict
Yes, if you’re a woman in perimenopause or menopause who wants a non-prescription supplement and is willing to give it three months alongside diet and activity. I gave Arrae MB-1 45+ 8.0 out of 10 for its menopause-focused formula of studied, branded ingredients, third-party testing, simple dosing, and strong ratings on Arrae’s own page. It isn’t higher because its numbers come from ingredient research rather than a study of the product, the blend hides individual amounts, and refunds cover only one jar. Check with your doctor first if you take any medicine or have thyroid, liver, or autoimmune conditions.
